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Figure 1.
Ribbons representation of different H2 HA monomers and
receptor binding sites. (A) Superposition of the monomers of two
human H2 HAs: A/Singapore/1/57 and A/Japan/305/57 colored green
and yellow respectively. (B) Three avian H2 HAs: A/ck/New
York/29878/91 colored gray, A/dk/Ontario/77 colored in blue and
A/ck/potsdam/4705/84 colored orange red. (C) Overlap of monomers
of a human H2 HA colored in green and avian H2 HA colored in
blue. The region highlighted by the gray ellipse at the top of
the panel shows the receptor binding domain, an expanded version
of which is shown in (D). Conserved residues such as Tyr-98,
Ser-136, Trp-153, and His-183 are shown in stick representation
together with other residues important in receptor binding
specificity such as Asn-186, Glu-190, and Leu-194, as well as
the Gln/Leu-226, Gly/Ser-228 pair.
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