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Figure 1.
Fig. 1. Structural overview of mCD1d–glycolipid complexes.
A schematic representation of the mCD1d–C8PhF complex is shown
in side view (a) and top view (b) rotated by 90° around the
x-axis from (a). The CD1d heavy-chain α1–α3 is highlighted
in light blue, β2m in light green, glycosylation sites as gray
sticks with red oxygens, C8PhF ligand in yellow, and A′-lipid
(AL), which is acquired from the cells during expression, in
blue. (c) Schematic drawings of the ligands used in this study.
The template α-GalCer is shown in black for comparison. Ligands
PBS-25, C6Ph, C8Ph, C8PhF, and C10Ph are derivatives of
α-GalCer, in which the C[26] fatty acid is replaced by either a
shorter fatty acid or a short fatty acid that terminates with a
phenyl ring.
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