|
Figure 1.
Fig. 1. (a) Schematic diagram of Saccharomyces cerevisiae U6
snRNA and its conformations in the free U6 snRNP, the U4-U6
di-snRNP, and the U2–U6 snRNA complex in the activated
spliceosome. The U6 ISL is indicated with a dashed box. (b)
Sequence and secondary structure of the U6 ISL used in this
study. The previously described A62G substitution that does not
affect the overall structure of the U6 ISL is indicated with a
box. The secondary structure is shown in the low-pH form, with a
protonated A79 (indicated with a +) and a bulged U80.
|
