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Figure 1.
(a) Chemical diagram of the pre-peptidyl-transfer state of
the ribosomal active site. In this structure, both the A- and
P-site tRNAs contain an amide linkage between residue A76 and
the phenylalanine amino acid. (b) Model of the ribosomal active
site in the pre-peptidyl-transfer state, including
representative 3F[o] – 2F[c] density for the A- and P-site
tRNAs in green and purple, respectively. (c) Chemical diagram of
the post-peptidyl-transfer state in which the A site contains an
amide-linked Phe-tRNA^Phe and the P site contains tRNA^fMet. (d)
Model of the post-peptidyl-transfer state within the peptidyl
transferase center, including 3F[o] – 2F[c] density for the A-
and P-site tRNAs in green and purple, respectively.
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