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Figure 1.
(a,b) Schematic representation of the reaction catalyzed by
the two CAAX prenyltransferases FTase and GGTase-I (a) or
RabGGTase in concert with REP (Rab escort protein) (b). The
enzymes catalyze the formation of a thioether linkage between
the prenyl group and one or two C-terminal cysteines of the
protein substrate. (c) Chemical structure of BGPP in comparison
with the natural substrates FPP and GGPP.
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