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Figure 1.
Figure 1: Overall structure and tertiary interactions of the
FMN-bound F. nucleatum riboswitch. a, Homology-based
schematic of the FMN riboswitch with key long-range interactions
indicated by arrows. RNA segments are depicted in colours used
for subsequent figures. b, Schematic of the riboswitch fold
observed in the crystal structure of the complex. The bound FMN
is in red. Key stacking interactions involving FMN are shown as
blue dashed lines. Nucleotides that are more than 95% conserved
among 183 FMN riboswitches are boxed. c, Overall riboswitch
structure in a ribbon representation. d, Superposition of the
P2–P6 (nucleotides 10–32 and 85–98) and P3–P5 domains
(nucleotides 62–84 and 33–46). The root mean square
deviation is 1.8 Å. e, f, Distinct alignments of
nucleotide triples in the P2–P6 (e) and P3–P5 (f) domains.
Dashed lines depict putative hydrogen bonds. Distances are in
ångstroms.
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