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Figure 1.
Figure 1. X-Ray Crystal Structure of NOD•ADP and
NOD•AMPPNP
(A) Structure of NOD•ADP is shown. ADP is
displayed as a ball-and-stick model.
(B) NOD•AMPPNP is
shown as in (A).
(C and D) Superposition of NOD•ADP
(blue) and NOD•AMPPNP (orange) through alignment of the P loop
(G87-S94) as viewed from the top (C) and from the side (D).
Arrows highlight the differences between the two states in Sw1,
Sw2, α3, and L11.
(E) Configuration of hydrogen bonds
between Sw1/Sw2 residues in NOD•ADP. Hydrogen bonds with
measured distances are highlighted with magenta dashed lines.
The water molecules that coordinate Mg^2+ are shown as red
spheres.
(F) Active site configuration of hydrogen bonds
for NOD•AMPPNP in a similar orientation as (E).
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