|
Figure 1.
Figure 1: Structure of SRA–DNA complex. a, Summary of the
SRA–DNA interactions; mc, main-chain-atom-mediated contacts;
w, water-mediated hydrogen bonds. Black boxes represent CpG
recognition sequence and K495-associated dotted lines represent
weak hydrogen bonds. b, The side chains of V451 of the base
flipping loop and R496 of the CpG recognition loop are in direct
van der Waals contact. c, The two loops—CpG recognition and
base flipping—penetrate into the DNA helix from opposite
directions. d, The 5mC flips out and binds in a cage-like
pocket. e, The surface charge at neutral pH is displayed as blue
for positive (20 k[B]T), red for negative (-20 k[B]T), and white
for neutral, where k[B] is the Boltzmann's constant and T is the
temperature.
|
