Figure 1.
Figure 1: Structure of the C-terminal domains of EscU and SpaS.
a, The native cleaved CTD of EscU and SpaS with a blue arrow
pointing to the auto-cleavage site. CTD is a novel /
-fold
with a mixed parallel and anti-parallel five-stranded twisted
-sheet
(topology 4,
1,
2,
3,
5)
flanked by two helices on each side ( 1,
2,
3
and 4).
b, Superposition of the CTD reveals a different fold for the
N-terminal linker between EscU, EscU mutants and SpaS, as well
as a longer C-terminal helix for SpaS.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2008,
453,
124-127)
copyright 2008.
/
-fold
with a mixed parallel and anti-parallel five-stranded twisted