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Figure 1.
The NKG2A/CD94/HLA-E complex structure. (A and B) Ribbon
representations of the complex viewed from the side (A) or from
above (B), colored by chain [NKG2A: red; CD94: green; HLA-E
heavy chain: blue; β[2]m: purple; peptide (showing all atoms):
yellow]. (C) Superpositions of α-carbon backbone traces of
NKG2A/CD94 crystallized in complex with HLA-E (showing the de
novo-built NKG2A model; NKG2A: dark green; CD94: dark red) and
alone (NKG2A: pale green; CD94: pale red; ref. 12). The
superpositions were aligned on CD94. Note that the structure of
the receptor in the complex includes residues 200–203 that are
absent from the free structure. (D) A schematic representation
of the contacts between NKG2A (red spheres)/CD94 (green spheres)
and HLA-E α1 (light blue) and α2 (dark blue) domains. An
asterisk indicates residues (HLA-E^R65, HLA-E^R79, HLA-E^E166,
NKG2A^R215) that are predicted to be involved in binding by
mutagenesis (12) but are not contacts in the structure.
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