Figure 1 - full size

Figure 1. Crystal structure of P51G-m4-CVN at 1.35 A resolution: cartoon representation of one monomer in complex with dimannose. Domain A (green) contains four mutations (K3N, T7A, E23I, N93A, highlighted as red sticks) in the binding site, resulting in loss of binding (Chang and Bewley 2002). Domain B (blue) is unaltered and binds to dimannose. A P51G mutation in the hinge region stabilizes the monomer (Barrientos et al. 2002). The sequence of P51G-m4-CVN is reported below; domains A and B are represented in green and blue, respectively, while mutations from wt are in red. Figure generated with PyMOL (DeLano Scientific; http://www.pymol.org).

The above figure is reprinted from an Open Access publication published by the Protein Society: Protein Sci (2008, 17, 939-944) copyright 2008.