Figure 1.
FIGURE 1. Ligation and hydrolytic reactions catalyzed by
trypanothione synthetase-amidase. Trypanothione is produced by
stepwise ligation of glutathione with spermidine (reaction I),
then glutathionylspermidine (reaction II). Hydrolysis of
trypanothione (reaction III) then glutathionylspermidine
(reaction IV) is performed by the N-terminal amidase domain.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2008,
283,
17672-17680)
copyright 2008.
