Figure 1.
Domain organization and location of tyrosine-phosphorylation
sites are drawn to linear scale (mouse numbering, 1,321
residues). Tyrosine-phosphorylation sites that are recruitment
sites for PI3K (Y XM
motif) are labeled by ^*, the GRB2 site (Y911) is labeled by †
and the two SHP2 sites (Y1242 and Y1303) are labeled by §.
The KRLB region as determined by Y2H studies (residues
591–733) is shown with dashed lines, and the 15-residue region
that was cocrystallized with IRK is shown in the gray box, with
the sequence expanded below and Tyr628 underlined. The
corresponding 15-residue sequence in IRS1 (mouse) is also shown.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Mol Biol
(2008,
15,
251-258)
copyright 2008.
XM
motif) are labeled by ^*, the GRB2 site (Y911) is labeled by †
and the two SHP2 sites (Y1242 and Y1303) are labeled by §.
The KRLB region as determined by Y2H studies (residues
591–733) is shown with dashed lines, and the 15-residue region
that was cocrystallized with IRK is shown in the gray box, with
the sequence expanded below and Tyr628 underlined. The
corresponding 15-residue sequence in IRS1 (mouse) is also shown.