Figure 1.
Figure 1. The currently accepted mechanism of asparagine
nonenzymatic deamidation.[11][12] The succinimide intermediate
formation arises from a nucleophilic attack of the backbone NH
group of the next residue on the side-chain carbonyl of the
asparaginyl residue. The ring is hydrolyzed to open, resulting
in either an aspartic acid or isoaspartic acid product.
The above figure is reprinted
by permission from John Wiley & Sons, Inc.:
Proteins
(2008,
72,
313-322)
copyright 2008.
