Figure 1.
FIGURE 1. Proposed mechanism for PGI[2] biosynthesis. A,
chemical structures of substrate PGH[2], substrate analog
U51605, and inhibitor minoxidil. B, a proposed mechanism for the
reaction catalyzed by PGIS (R1, CH[2]-(CH[2])[2]-COOH; R2,
CH-CHOH-(CH[2])[4]-CH[3]) (6).
The above figure is reprinted
from an Open Access publication published by the ASBMB:
J Biol Chem
(2008,
283,
2917-2926)
copyright 2008.
