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Figure 1.
(a) Structure of 3MBT bound to an H4K20me2 peptide (residues
17–25). H4K20me2 peptide is shown in red and the
dimethyllysine is shown as a stick model. (b) Sequence alignment
of MBT2, MBT1 and MBT3. Red, identical; blue, conserved; dots,
lysine-binding pocket residues. (c) Superimposition of the three
MBT repeats in 3MBT. Residues forming the lysine-binding pocket
are shown as green sticks, and Phe256 from MBT1 and Arg467 from
MBT3 are colored pink and blue, respectively. H4K20me2 peptide
is shown as yellow sticks.
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