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Figure 1.
Figure 1. Structure of Npl3. (a) Ribbon diagrams of the two
RRM domains of Npl3 as determined by NMR; the two domains are
structurally independent and connected by an eight residue
flexible linker. (b) and (c) Overlays of the 20 lowest energy
structures on the left, and ribbon representations of the lowest
energy structure on the right. Structures for RRM-1 and RRM-2
are shown in (b) and (c), respectively; the two domains are
shown separately here for clarity of presentation. (d) Amino
acid sequence for the full-length Npl3 protein. Residues
121–280 were the subject of NMR structure determination;
residues belonging to RRM-1 and RRM-2 are colored blue and pink,
respectively.
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