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Figure 1.
Figure 1. Monomer and tetramer structures of H. pylori ENR and
electron density maps of the bound ligands. (A) Monomer
structure. Secondary structure elements were defined by PyMOL
(DeLano, 2002, The PyMOL Molecular Graphics System,
http://pymol.sourceforge.net/). NAD^+ and triclosan bound to the
active site of subunit A are shown as ball-and-stick models. (B)
Tetrameric architecture. NAD^+ and triclosan are shown. (C)
2F[o]-F[c] electron density maps of the bound ligands,
superimposed on triclosan (subunit A), diclosan (subunit A), and
NAD^+ (subunit A of the triclosan complex). (D) Superposition of
triclosan (cyan) and diclosan (purple). Phenolic rings (ring A)
of triclosan and diclosan are superimposed.
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