Figure 1.
Figure 1 Structure of the human HDAC8–substrate complex. (A)
Ribbon diagram of the two HDAC8–substrate complexes in the
asymmetric unit. The substrate and residues involved in the
head-to-head packing are shown in a stick representation.
Carbon, oxygen and nitrogen for the substrate are green, red
and blue, respectively. Zn^2+ and K^+ ions are represented as
purple spheres. (B) Enlarged view of the substrate-binding site
in the asymmetric unit with the 1.0 -contoured
2F[o]-F[c] electron density map. (C) HDAC8 monomer with the
bound substrate. Atoms are coloured as in (A). (D) Enlarged view
of the active site. Polar interactions are shown as dashed
yellow lines. HDAC, histone deacetylase.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
EMBO Rep
(2007,
8,
879-884)
copyright 2007.
-contoured
2F[o]-F[c] electron density map. (C) HDAC8 monomer with the
bound substrate. Atoms are coloured as in (A). (D) Enlarged view
of the active site. Polar interactions are shown as dashed
yellow lines. HDAC, histone deacetylase.