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Figure 1.
Figure 1. MART-1[26/27–35]-based peptides adopt one of two
general conformations in the HLA-A2 peptide-binding groove. (a)
Superimposition of the native AAG nonamer and the P2-modified
ALG nonamer solved here and by Sliz et al.,^24 identifying the
extended conformation. (b) Superimposition of the native EAA
decamer, the P2-modified ELA decamer solved by Sliz et al., and
the P1-modified LAG nonamer, identifying the bulged
conformation. (c) Stereo image comparing the extended
conformation of the native AAG nonamer and the bulged
conformation of the ELA decamer. (d) Same as in (c), but rotated
90° out and showing the surface of HLA-A2 as partially
transparent. All superimpositions are via the backbones of P1
and P6−P9.
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