|
Figure 1.
(a) Chemical structures of neomycin, paromomycin and
gentamicin. (b) Global view of the ribosome and the two binding
sites for aminoglycosides. Gold and green, aminoglycosides bound
to the 30S and 50S subunits, respectively; light blue, 16S rRNA;
gray, 23S rRNA; purple, 5S rRNA; dark blue and magenta, proteins
of small and large subunits, respectively; CP, central
protuberance. (c) Close-up view of the two binding sites in h44
and H69, shown with neomycin as an example. Neomycin molecules
bound to h44 and H69 are in gold and green, respectively. Green,
orange and blue shadows outline positions that would be occupied
by mRNA, A-site tRNA and P-site tRNA, respectively. The mRNA and
tRNAs are above the plane of the image. Inset shows direction of
view.
|
