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Figure 1.
Fig. 1. (A) Chemical structures of MK-591 and (B) an iodinated
analog of MK-591. (C) The FLAP monomer viewed parallel to the
nuclear membrane with red helices and green loops. The
unstructured C terminus of FLAP (residues 141 to 161) extends
beyond G140. (D) The FLAP trimer with monomers colored green,
cyan, and magenta. The view is given parallel to the nuclear
membrane. Bound inhibitor molecules are shown as stick models
with yellow carbon atoms, blue nitrogen atoms, red oxygen atoms,
and purple iodine atoms.
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