Figure 1.
Fig. 1. The overall complex structure of c-JMJD2A with the
H3K36me3 peptide in the presence of NOG (orange), Fe(II) (pink),
and Zn (purple). (A) c-JMJD2A is shown as a ribbon model with
the Jumonji N domain (green), the long hairpin (purple), the
mixed structural motif (gray), the Jumonji C domain (light
blue), the C-terminal domain (pink), and the methylated H3K36
peptide (yellow). Seventeen of the 22 residues (residues 27–43
from histone 3) of the methylated peptide are ordered in the
structure (molecule A). (B) A stick and ball model of the
peptide on the surface of c-JMJD2A colored according to the
electrostatic potential of the residues (red and blue represent
negatively and positively charged areas, respectively). All
structural figures were made by using the PyMOL program
(http://pymol.sourceforge.net).
hairpin (purple), the
mixed structural motif (gray), the Jumonji C domain (light
blue), the C-terminal domain (pink), and the methylated H3K36
peptide (yellow). Seventeen of the 22 residues (residues 27–43
from histone 3) of the methylated peptide are ordered in the
structure (molecule A). (B) A stick and ball model of the
peptide on the surface of c-JMJD2A colored according to the
electrostatic potential of the residues (red and blue represent
negatively and positively charged areas, respectively). All
structural figures were made by using the PyMOL program
(http://pymol.sourceforge.net).