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Figure 1.
FIGURE 1. Crystal structure of LSD1-CoREST in complex with
pLys4Met H3 peptide. A, ribbon diagram of the structure. LSD1 is
in blue, CoREST in red, and the peptide in green. The FAD
cofactor is shown as a yellow ball-and-stick. The final model
consists of residues 171–836 of LSD1, residues 308–440 of
CoREST, and residues 1–16 of pLys4Met peptide. B, fitting of
the refined pLys4Met peptide in the unbiased electron density
calculated with weighted 2F[o] – F[c] coefficients. The map
was calculated prior inclusion of the peptide atoms in the
refinement calculations. The contour level is 1.2  , and
the resolution is 3.1 Å. The sequence of the histone H3
peptide used for the x-ray analysis is
^1ARTMQTARKSTGGKAPRKQLA^21.
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