Figure 1.
Figure 1. FabH Inhibition by Alkyl-CoA Disulfides (A)
Chemical structures of alkyl-CoA disulfides 1–5. (B)
Proposed mechanism of ecFabH inactivation by MeSSCoA (1). Cys112
of ecFabH forms a methyl disulfide conjugate upon incubation
with MeSSCoA (1). The released CoA in the CoA binding channel
may be retained or dissociated.
The above figure is reprinted
by permission from Cell Press:
Chem Biol
(2007,
14,
513-524)
copyright 2007.
