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Figure 1.
Figure 1. Crystal structure of the Daam1 FH2 domain. (a) The
domain structure of human Daam1. (b) Ribbon diagram showing the
overall structure of Daam1 FH2 domain. Sub-domains including the
lasso, the knob, the coiled-coil and the post region are
labeled. The invisible linker region is drawn manually with a
broken line for the purpose of illustration. The molecule is
colored using the visible spectrum (from blue at the N terminus
to red at the C terminus). (c) Ribbon diagram of the structure
of Daam1 FH2 dimer. The broken line separates the two
hemidimers. One molecule is colored the same way as in (b),
while the other is colored tan. (d) Sequence alignment and
secondary structure of the FH2 and DAD domains. Aligned
sequences are from human Daam1, murine Daam1, human Daam2,
murine Daam2, murine Dia1 and yeast (Saccharomyces cerevisiae)
Bni1p. Secondary structure elements are shown above the
sequences, with rectangles representing helices and thin lines
indicating non-helical regions. Conserved residues are colored
red. Figures were prepared using the program PyMoL [Delano,
W.L., The PyMol Molecular Graphics System (2002)
http://www.pymol.org].
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