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Figure 1.
(a) Reaction mechanism for a type 1 cap. (b) VP4 domain
organization (domain names defined in text). Poorly ordered
loops are gray. Contact areas between domains are indicated. (c)
VP4 colored by domain, with active sites and ligands colored as
in a; view rotated 120° from b. AdoHcy in N7MTase and
2'OMTase are azure and orange, respectively. Cap analog is
yellow. (d) Active sites mapped onto electrostatic surface
representation of VP4 (colored as in c), and VP4 within BTV core.
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