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Figure 1.
Figure 1 Structure of the complete 270 kDa Sulfolobus
solfataricus exosome. (A) Two views of the complex, with Rrp41
in blue, Rrp42 in green and Rrp4 in yellow. Manganese ions are
shown in cyan. The views are rotated by 90° around the
horizontal axis. This figure and all others representing
structures were generated with the program PYMOL
(http://pymol.sourceforge.net, Warren L. DeLano). (B) View of
the S. solfataricus exosome (Rrp4 in yellow, and Rrp41 and Rrp42
in light grey) superposed on the A. fulgidus exosome using the
RNase PH cores (Rrp4 in red, Rrp41 and Rrp42 in dark grey). The
structures are viewed as in (A), left. The three domains of Rrp4
(N-terminal, S1 and KH) are indicated. (C) View of the S.
solfataricus exosome superposed on the human exosome using the
RNase PH cores (light grey for S. solfataricus and dark grey for
human RNase PH). Ss-Rrp4 is shown in yellow, Hs-Rrp40 in
magenta, Hs-Rrp4 in green and Hs-Csl4 in pink. Csl4, cep1
synthetic lethality; Hs, Homo sapiens; Rrp, ribosomal RNA
processing factor; Ss, Sulfolobus solfatarious.
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