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Figure 1.
Figure 1. Overall structure of the open and closed complexes.
(a) The diagram shows a schematic representation of the closed
complex (Form I, pH 5.5). The four major domains of the protein
are colored red, blue, purple, and green for domain I, II, III,
and IV, respectively. The active site is found at the
intersection of domains I and III. The ssDNA binding groove
extends from domain IV to the active site. The ssDNA in the
complex is shown in a ball and stick representation. (b)
Schematic diagram of the open complex (Form II, pH 5.5),
colored as in (a). (c) Stereo view showing the superposition of
the closed (red), intermediate (blue), and open (green)
complexes. The structures were aligned by superposing domain I
only. The three structures correspond to Form I pH 5.5, Form II
pH 8.0, and Form II, pH 5.5.
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