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Figure 1.
Fig. 1. Pol II elongation complex structures with
thymine-thymine CPD lesions in the template. (A) Nucleic acid
scaffolds A to D. The color code is used throughout. Filled
circles denote nucleotides with interpretable electron density
that were included in the structures in (B). Open circles denote
nucleotides having electron density that could not be
interpreted or that was lacking. (B) Structure of nucleic acids
in the Pol II elongation complexes A to D. The view is from the
side (11). Figures prepared with PYMOL (DeLano Scientific). (C)
Overview of complex C with a CPD lesion at the active site. The
view is as in (B). Protein is in gray, the bridge helix in
green. The CPD is shown as a stick model in orange. A large
portion of the second largest Pol II subunit was omitted for
clarity. (D) Superposition of nucleic acids in structures A to
D. The protein molecules were superimposed and then omitted. The
nucleic acids are depicted as ribbon models, the CPDs as stick
models. Upper and lower views are related by a 90° rotation
around a horizontal axis.
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