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Figure 1.
Figure 1. Overall structure of U2AF^65-RRM1. Alternative
conformations are shown as ball-and-stick representations with
the major conformation in yellow and the minor conformation in
red. (a) Ribbon diagram of U2AF^65-RRM1 with α-helices in blue
and β-strands in green. Bound PEG MME550 and zinc ions from the
crystallization solution are shown in magenta. (b) View as in
(a), rotated 180° about the y-axis. (c) Backbone trace
representations of U2AF^65-RRM1 (blue) compared with X-ray
structures of other RRMs determined in the absence of RNA,
including the N-terminal RRM of U1A^24 (purple), N and
C-terminal RRMs of Sex-lethal^16 (red and green, respectively),
and N and C-terminal RRMs of hnRNP A1^17 (yellow and cyan,
respectively). The unique α1/β2 loop and β2/β3 loop of
U2AF^65-RRM1 are labeled. Images were created using
MolScript,^25 Bobscript,^26 and Raster3D.^27
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