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Figure 1.
Figure 1 Crystal structure of dimerized radixin FERM domains.
(a) Overall structure as a ribbon model. Mol-1 is shown in light
blue and Mol-2 in pink, with its C-terminal extended residues
(Arg295-Gln304) in red. The radixin FERM domain consists of
subdomains A (the N-terminal 82 residues), B (residues 96-119)
and C (residues 204-297). (b) A side view shows that Mol-1 and
Mol-2 are aligned in a similar orientation. The blue dashed line
represents the membrane-interaction surface of a dimer and blue
arrows indicate binding sites to phosphatidylinositol
4,5-bisphosphate (PIP2; Hamada, Shimizu et al., 2000[Hamada, K.,
Shimizu, T., Matsui, T., Tsukita, S. & Hakoshima, T. (2000).
EMBO J. 19, 4449-4462.]). Figures were prepared using PyMOL
(http://pymol.sourceforge.net ). (c) Schematic representation of
the interactions between the C-terminal extended residues
(strand 2 in pink) and subdomain C (light blue). Hydrogen bonds
are shown as dashed lines and distances are indicated.
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