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Figure 1.
Figure 1. Human pol g-b shares structural homology with E.
coli threonyl tRNA synthetase (ThrRS). (a) Ribbon display of the
human pol g-b structure. The N and C-terminal domains and HLH-b3
domain of monomer A are colored light green, green, and cyan,
respectively. Monomer B is in gray. (b) Superposition of the
N-terminal (upper panel) and C-terminal (lower panel) domains of
human pol g-b (blue) on the catalytic and anticodon binding
domains of ThrRS,44 respectively. (c) RNA operator (yellow, PDB
code 1KOG),12 tRNA (green, PDB code 1QF6),11 and DNA (orange,
PDB code 1T7P),13 were docked onto the electrostatic surface of
the pol g-b dimer. (d) The electrostatic surface of the ThrRS
dimer with bound tRNA (green) and RNA operator (yellow).
Surfaces in (c) and (d) are colored according to electrostatic
potential (red, -7.5kT/e^ - to blue, +7.5kT/e^ -).
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