Figure 1.
Fig. 1. Structural features of pVirB8^AT and comparison
with pVirB8^BS. Monomer A is colored magenta and cyan and
monomer B is gray. (A) Ribbon representation of monomer A with
secondary structure elements labeled. (B) Surface rendered image
of pVirB8^AT in same orientation as A showing the deep groove.
The surface is colored according to the secondary structure:
cyan for helical segments, pink for -strands, and gray for
loops. (C) C trace of superimposed
pVirB8^AT (green with regions of greatest divergence highlighted
in cyan) and pVirB8^BS (blue) monomers. (D) Ribbon diagram of
the dimer rotated 90° with respect to A. Boxes indicate the
three dimer contact regions. The side chains of Arg-107,
Asp-113, Asp-115, Thr-116, Tyr-119, and Arg-157 are shown, and
two 2-methyl-2-4-pentanediol molecules (yellow) are shown as
stick models. (E–G) correspond to boxes D1, D2, and D3 and
show details of the three dimer contact regions viewed down the
dimer axis, equivalent to a 90° rotation from the view in D.
(E) Residues involved in the major region of dimer contact. (F)
Interactions across the central channel between the monomers.
(G) Four aspartates at the lowest level of the interface.
-strands, and gray for
loops. (C) C 
trace of superimposed
pVirB8^AT (green with regions of greatest divergence highlighted
in cyan) and pVirB8^BS (blue) monomers. (D) Ribbon diagram of
the dimer rotated 90° with respect to A. Boxes indicate the
three dimer contact regions. The side chains of Arg-107,
Asp-113, Asp-115, Thr-116, Tyr-119, and Arg-157 are shown, and
two 2-methyl-2-4-pentanediol molecules (yellow) are shown as
stick models. (E–G) correspond to boxes D1, D2, and D3 and
show details of the three dimer contact regions viewed down the
dimer axis, equivalent to a 90° rotation from the view in D.
(E) Residues involved in the major region of dimer contact. (F)
Interactions across the central channel between the monomers.
(G) Four aspartates at the lowest level of the interface.