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Figure 1.
Fig. 1. X-ray structure of the suPAR-ATF-ATN615 complex. (A)
Stereo view of the structure of the suPAR-ATF-ATN615 complex. In
the ribbon diagram of the ternary complex, the D1 domain of
suPAR is shown in orange, the D2 domain in magenta, and the D3
domain in green. The ATF is shown in cyan, light chain of the
antibody ATN615 in light blue, and the heavy chain in dark blue.
Carbohydrates in suPAR are shown as red sticks. Disulfide bonds
are shown in dashed lines colored as is the backbone to which
they are attached. (B) Ribbon structure of ATF. The GFD domain
is shown in cyan and the kringle domain in dark salmon. The
residues Leu14, His41, Ile^44, Asp45, Arg59, Leu92, and Tyr101
involved in domain interactions are shown as sticks.  -loop (residues
23 to 29) connects two ß strands (residues 18 to 22 and 30
to 32) in the GFD domain. The kringle domain contains two
strands (residues 112 to 117 and 120 to 125) and two short  helices (78 to 81
and 91 to 94). All figures were made by PyMOL (23).
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