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Figure 1.
Figure 1. Conformation of HIV-1 protease NL4-3 in complex
with the inhibitor TL-3. TL-3 forms an intricate hydrogen
bonding network with wild-type NL4-3 protease. The network
between TL-3 and residues in the catalytic loop and flap regions
is mediated by seven ordered water molecules (W1-W4, W1'-W3').
The majority of the protein-inhibitor hydrogen bonds are formed
between main-chain atoms. See Table 2 for hydrogen bond
distances. The positions of Met46 and Phe53 are indicated in
parentheses. This Figure and Figure 2, Figure 4 and Figure 5
were generated using WebLab ViewerLite 3.20 (Accelrys, San
Diego, CA, USA).
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