Figure 1 - full size

 

Figure 1.
Figure 1. Multiple alignment of the editing domain of AlaRS and ThrRS enzymes. Residues involved in coordination of the zinc ion (red) and highly conserved residues (yellow) are indicated. The secondary structure elements in the crystal structure of PH0574 (above) and ecThrRS (below) are shown in the alignment. GenBank accession numbers given in parentheses are PH0574 (NP_142539), mbAlaX (ZP_00296079), pfAlaRS (NP_577999), ecAlaRS (NP_417177), saThrRS (NP_646443, PDB ID: 1NYR), ecThrRS (NP_416234, PDB ID: 1QF6).

The above figure is reprinted by permission from John Wiley & Sons, Inc.: Proteins (2006, 62, 1133-1137) copyright 2006.