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Figure 1.
Figure 1 gD(23-306)[307C] structure. (A) Schematic
representation of HSV-1 gD. Disulfide bonds are shown as black
lines and N-linked oligosaccharides as lollipops. Colors of the
N-terminal region, forming the HVEM-binding hairpin in the
gD285-HVEM complex, the Ig-like core, and the C-terminal region
past residue 255 are represented in green, yellow, and red,
respectively. Positions of important amino acids and domain
boundaries are numbered according to the mature form of gD. TM:
transmembrane region. (B) Ribbon representation of the
gD(23-306)[307C] subunit. The secondary structure elements are
labeled as in Carfi et al (2001). The color code used is same as
in (A). (C) As in (B) after 180° rotation as indicated. (D)
Front view of gD(23-306)[307C] structure. The model is rotated
90° clockwise with respect to panel B to show the front side of
gD, where the N- and C-terminal regions interact. (E) Front view
of gD285 from the gD285-HVEM complex, with HVEM removed for
clarity. (F) Front view of gD285 in the unbound state.
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