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Figure 1.
FIGURE 1. Structure of lipoamide dehydrogenase from M.
tuberculosis. A, ribbon representation of LPD dimer. Protomers
are colored blue or red. N and C demarcate the blue and red
polypeptide termini, respectively. Residues (Cys-41, Cys-46,
His-443', Glu-448') within the active sites are shown in stick
representation. FAD and the active site are indicated by arrows
and labeled. B, Stereo view and close-up of the active site with
respective active site residues in A labeled with putative
hydrogen bonds depicted as gray dashed lines. A simulated
annealing "omit" map is shown contoured around the FAD cofactor
at 1.0  . Structural
representations prepared with PyMol unless otherwise indicated
(34).
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