Figure 1.
Figure 1. (A) Scheme for the reaction carried out by FTCD_CD
(EC 4.3.1.4), which catalyzes the cyclization of the formimino
group of N^5-formimidoyltetrahydrofolate, yielding
N^5,N^10-methenyltetrahydrofolate and ammonia. (B) Crystal
structure of TM1560. Ribbon diagram of T. maritima FTCD_CD
color-coded from N-terminus (blue) to C-terminus (red) showing
the domain organization. elices
H1-H6 are indicated. (C) The TM1560 dimer view is shown along
(above) and normal (below) to its two-fold axis. (D) Diagram
showing the secondary structure elements in TM1560 superimposed
on its primary sequence. The -helices,
3[10]-helices, -bulges,
and -turns
are indicated. Disordered regions are depicted by a dashed line
with the corresponding sequence in brackets.
The above figure is reprinted
by permission from John Wiley & Sons, Inc.:
Proteins
(2005,
58,
976-981)
copyright 2005.
elices
H1-H6 are indicated. (C) The TM1560 dimer view is shown along
(above) and normal (below) to its two-fold axis. (D) Diagram
showing the secondary structure elements in TM1560 superimposed
on its primary sequence. The 
-helices,
3[10]-helices, 
-bulges,
and 
-turns
are indicated. Disordered regions are depicted by a dashed line
with the corresponding sequence in brackets.