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Figure 1.
FIG. 1. A, synthesis key intermediates. a, (i) LiCl,
N,N-dimethylformamide 150 °C; (ii) BnCl, K[2]CO[3]. b, H[2],
Pd/C, MeOH. c, t-butyldi-methylsilylchloride, imidazole. d (i)
t-BuLi, B(OMe)[3], (ii) H[2]O[2]/AcOH. e, Cs[2]CO[3], EtI,
N,N-dimethylformamide. f, t-BuLi, N,N-dimethylformamide. B,
synthesis of G17905 [GenBank]
. a, tosylmethylisocyanide, BF[3]OEt[2], MeOH/H[2]O. b, LiOH,
tetrahydrofuran/H[2]O. c, CDI, m-nitrobenzene sulfonamide, DBU,
tetrahydrofuran. d, H[2]/C/Pd. e, (i) EtOH, HCl; (ii) MeOH,
NH[3]. f, reverse phase chiral chromatographic separation,
S-WELK-O column, isopropyl alcohol, pH 5.5.
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