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Figure 1.
Figure 1. The Overall Fold of IP[3]-3K Catalytic Domain(A)
A ribbon diagram of IP[3]-3K in a complex with
Mn^2+/AMPPNP/Ins(1,4,5)P[3]. The N lobe is colored orange, the C
lobe yellow, the IP lobe purple, and the hinge green. The
conserved IDFG, GSSLL, and DxK motifs are colored pink, cyan,
and brown, respectively. This and all other molecular
illustrations were prepared with PYMOL.(B) A topology diagram of
the catalytic domain. Helix α0[N] is ordered only in the
absence of substrates or products. The dashed arrow indicates an
additional strand that would be characteristic of the N lobes of
PKs.(C) Ribbon diagrams of the catalytic domains of PI3Kγ and
PIPKIIβ with N and C lobes colored as in (A).
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