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Figure 1.
FIG. 1. Overall structure of the open and closed
conformation that ProX undergoes in a large conformational
change from its unliganded open conformation (left) to the
liganded closed form (right). In between (above the arrow) the
three structures, ligands are shown that have been found to
induce this conformational change, GB, PB, and TM, from left to
right. Domain A (blue) is shown in the same orientation for both
conformations, whereas the comparison shows that domain B
(yellow) is relocated with respect to domain A. In the closed
conformation the ligand GB is highlighted in red.
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