Figure 1 - full size

Figure 1. Figure 1. Schematic of the Genomic Environment and a Typical Acetyltransferase Reaction of AAC(6′)-Iy(A) The genomic environment of the aminoglycoside-sensitive S. enterica BM4361 and aminoglycoside-resistant S. enterica BM4362. A 60 kilobase pair chromosomal deletion results in the constitutive nmpC promoter (black circle) being placed vert, similar 2.2 kilobases upstream of the aac(6′)-Iy-encoded aminoglycoside acetyltransferase (red arrow).(B) Ribostamycin acetylation catalyzed by aminoglycoside 6′-N-acetyltransferase.

The above figure is reprinted by permission from Cell Press: Chem Biol (2004, 11, 565-573) copyright 2004.