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Figure 1.
Figure 1 Proposed electron flow from reduced thioredoxin in the
cytoplasm to oxidized, homodimeric DsbC in the periplasm via
DsbD. According to this mechanism, electron transport occurs
exclusively through intermolecular and intramolecular disulfide
exchange. DsbD consists of an N-terminal domain (nDsbD, residues
1 -143) and a C-terminal domain (cDsbD; residues 419 -546),
which are oriented toward the periplasm, and a central TM domain
(residues 144 -418). Numbered circles represent essential
cysteine residues in the respective protein.
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