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Figure 1.
Fig. 1. Models of hexanucleotide binding in the active
site of RTA(based upon [10]). The structures are shown as stereo
images with the C[1]G[2]A[3]G[4]A[5]G[6] (where A[3] is the
target for depurination by RTA) in red. C[1] of the
hexanucleotide is at the bottom left and the target adenine is
at the top of each model. The sidechains of RTA are shown in
blue. (A) Model 1 has the tetraloop bound in the active site of
RTA with G[4] stacked upon the G[2]-A[5] pair and able to make
interactions with Asn122. (B) Model 2 is a variation of model 1
with the tetraloop bound in a conformation where G[4] stacks
with Tyr80 and makes interactions with Asp75 and Asn78. Drawn
with MOLSCRIPT[34,35].
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