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Figure 1.
Figure 1. The crystal structure of the HPV 6 E2 DNA-binding
domain. (a) Topology of the HPV 6 E2 DBD monomer. (b) Topology
of the HPV 6 E2 DBD dimer. The subunits are indicated in red and
blue. (c) A comparison of the DBDs from the HPV 6 (blue), HPV 16
(red), and BPV1 (yellow) E2 proteins. The left subunit of each
protein is superimposed. (d) A comparison of the b2/b3 loop in
the HPV 6 E2 DBD (blue) and BPV1 E2 DBD (yellow). BPV1 E2 Arg370
is indicated in pink. HPV 6 E2 Lys327, Lys323, Asp311 and His366
are indicated in light blue. His366 is present in two
conformations in the crystal structure.
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