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Figure 1.
Fig. 1. TBB binding to pCDK2–cyclin A.(A) Schematic
representation of the structure of pCDK2 (yellow) and cyclin A
(magenta) in complex with TBB (carbon atoms, green; nitrogen
atoms, blue; and bromine atoms, cyan). TBB binds at the ATP
binding site in the region between the N- and C-terminal lobes
and makes contacts with residues in the hinge region. (B)
Details of TBB fit to the final sigmaa weighted 2Fo-Fc electron
density map. The map is contoured at levels corresponding to 1
 (blue
contours) and 4 (red
contours). The position of ATP is shown superimposed (carbon
atoms: black). These figures and those in Fig. 2 Go- were
prepared with aesop (M. E. M. Noble, unpublished work).
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