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Figure 1.
Fig. 1. Structures of the trimeric AcrB transporter with bound
ligands viewed from the side parallel to the membrane. (A) AcrB
with three bound R6G molecules. The figure shows the
transmembrane domain (inner and outer leaflets), the periplasmic
domain, and the location of cavity, vestibule, pore, and funnel
(8). The drugs are bound approximately at the level of the outer
surface of the membrane lipid bilayer. (B) through (D) show the
center of the side view in (A), with bound Et, Dq, and Cip
molecules. This figure and Fig. 2 were prepared with PyMOL (22).
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