Figure 1.
Figure 1. Ribbon diagram of the M. tuberculosis
pantothenate synthetase dimer. (A) A side view of the dimer
structure showing that it resembles the shape of a butterfly.
(B) An orthogonal view of (A) from top, with the twofold NCS
symmetry axis (labeled with a dot) approximately perpendicular
to the paper plane. Secondary structure elements for the subunit
A (left) are labeled. Those for subunit B are identical except
that the short helix 3' is not
present. The figure was prepared from the coordinates of the
intermediate complex (data set 5), with the program Molscript
(Kraulis 1991) and Raster3D (Merritt and Murphy 1994). The
molecule in the active site of each subunit, shown in
ball-and-stick, is the reaction intermediate, pantoyl adenylate.
The above figure is reprinted
by permission from the Protein Society:
Protein Sci
(2003,
12,
1097-1108)
copyright 2003.
3' is not
present. The figure was prepared from the coordinates of the
intermediate complex (data set 5), with the program Molscript
(Kraulis 1991) and Raster3D (Merritt and Murphy 1994). The
molecule in the active site of each subunit, shown in
ball-and-stick, is the reaction intermediate, pantoyl adenylate.